Beyond 75: Graft Allocation and Organ Utility Implications in Liver Transplantation.

ABSTRACT:

Background

The global surge in aging has intensified debates on liver transplantation (LT) for candidates aged 75 y and older, given the prevalent donor scarcity. This study examined both the survival benefits and organ utility of LT for this age group.

Methods

A total of 178 469 adult LT candidates from the United Network for Organ Sharing database (2003-2022) were analyzed, with 112 266 undergoing LT. Post-LT survival outcomes and waitlist dropout rates were monitored across varying age brackets. Multivariable Cox regression analysis determined prognostic indicators. The 5-y survival benefit was assessed by comparing LT recipients to waitlist candidates using hazard ratios. Organ utility was evaluated through a simulation model across various donor classifications.

Resu

SUBMITTER: Akabane M 

PROVIDER: S-EPMC11446594 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature