Skeletal muscle mass and quality in gout patients versus non-gout controls: A computed tomography imaging study.

ABSTRACT:

Objective

Patients with gout are at elevated risk of multiple vascular and metabolic comorbidities. Whether they are also at risk of sarcopenia, which is known to affect patients with other rheumatic diseases, has not been previously assessed. We examined whether patients with gout have decreased lumbar muscle quality and quantity, indicating an association between gout and sarcopenia.

Methods

Fifty gout subjects and 25 controls, ages 45-80, underwent computed tomography imaging of the lumbosacral spine. We measured muscle quantity (skeletal muscle area [SMA] and index [SMI]) and quality (skeletal muscle radiation attenuation [SMRA] and intermuscular adipose tissue [IMAT] area and index [IMATI]) of the psoas and erector spinae muscles at the L3 level.

Results

Seventy

SUBMITTER: Covello A 

PROVIDER: S-EPMC11446650 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature