Free essential amino acid feeding improves endurance during resistance training via DRP1-dependent mitochondrial remodelling.

ABSTRACT:

Background

Loss of muscle strength and endurance with aging or in various conditions negatively affects quality of life. Resistance exercise training (RET) is the most powerful means to improve muscle mass and strength, but it does not generally lead to improvements in endurance capacity. Free essential amino acids (EAAs) act as precursors and stimuli for synthesis of both mitochondrial and myofibrillar proteins that could potentially confer endurance and strength gains. Thus, we hypothesized that daily consumption of a dietary supplement of nine free EAAs with RET improves endurance in addition to the strength gains by RET.

Methods

Male C57BL6J mice (9 weeks old) were assigned to control (CON), EAA, RET (ladder climbing, 3 times a week), or combined treatment of EAA and RET

SUBMITTER: Jang J 

PROVIDER: S-EPMC11446676 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature