Higher serum uric acid as a risk factor for frailty in older adults: A nationwide population-based study.

ABSTRACT:

Background

Uric acid (UA), the terminal breakdown product of purine metabolism, possesses contradictory roles, functioning both as an inflammatory mediator and as an antioxidant. Its clinical relevance, particularly in geriatric populations, remains a topic of ongoing debate. Aiming to elucidate whether circulating UA is detrimental or beneficial to human health, we investigate the association between serum UA concentrations and the frailty index-a comprehensive measure of biological aging in a nationally representative cohort of community-dwelling older adults.

Methods

We conducted a population-based, cross-sectional study utilizing data from the Korea National Health and Nutrition Examination Survey. The sample included 4268 participants aged 65 years and above. A deficit

SUBMITTER: Kang MG 

PROVIDER: S-EPMC11446678 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature