Mitochondrial bioenergetics are not associated with myofibrillar protein synthesis rates.

ABSTRACT:

Background

Mitochondria represent key organelles influencing cellular homeostasis and have been implicated in the signalling events regulating protein synthesis.

Methods

We examined whether mitochondrial bioenergetics (oxidative phosphorylation and reactive oxygen species (H₂O₂) emission, ROS) measured in vitro in permeabilized muscle fibres represent regulatory factors for integrated daily muscle protein synthesis rates and skeletal muscle mass changes across the spectrum of physical activity, including free-living and bed-rest conditions: n = 19 healthy, young men (26 ± 4 years, 23.4 ± 3.3 kg/m²) and following 12 weeks of resistance-type exercise training: n = 10 healthy older men (70 ± 3 years, 25.2 ± 2.1 kg/m²). Additionally, w

SUBMITTER: Holwerda AM 

PROVIDER: S-EPMC11446679 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature