The association between dynamic changes in vitamin D and frailty alterations: A prospective analysis of UK Biobank participants.

ABSTRACT:

Background

Frailty is a common geriatric syndrome associated with reduced reserves and increased vulnerability to stressors among older adults. Vitamin D deficiency has been implicated in frailty, as it is essential for maintaining musculoskeletal functions. The relationship between dynamic changes in vitamin D levels and frailty over time has not been extensively studied.

Methods

This study utilized data from the UK Biobank. Baseline and longitudinal changes in vitamin D levels were measured. Frailty status was assessed using both the frailty phenotype and frailty index approaches and classified as robust, pre-frail, or frail. Changes in frailty status were assessed by frailty phenotype at baseline (2006-2010) and the follow-up (2012-2013). Mixed effect model was performed

SUBMITTER: Zhang P 

PROVIDER: S-EPMC11446684 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature