Myosteatosis and muscle loss impact liver transplant outcomes in male patients with hepatocellular carcinoma.

ABSTRACT:

Background

Sarcopenia is associated with unfavourable long-term survival in patients undergoing liver transplantation (LT) for hepatocellular carcinoma (HCC). However, the impact of myosteatosis and muscle loss on patient prognosis has not been investigated.

Methods

Seven hundred fifty-six HCC patients who received LT at 3 transplant centres were included. Computed tomography (CT) images of recipients were collected to measure skeletal muscle index (SMI) and skeletal muscle radiodensity (SMRA). The impact of myosteatosis on the prognosis of sarcopenic and non-sarcopenic patients was studied separately. Muscle status was evaluated based on the presence of sarcopenia and myosteatosis. The muscle loss of 342 males was calculated as the relative change of SMI between pre- and po

SUBMITTER: Lu D 

PROVIDER: S-EPMC11446693 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature