Sarcopenia-related changes in serum GLP-1 level affect myogenic differentiation.

ABSTRACT:

Background

Sarcopenia, a group of muscle-related disorders, leads to the gradual decline and weakening of skeletal muscle over time. Recognizing the pivotal role of gastrointestinal conditions in maintaining metabolic homeostasis within skeletal muscle, we hypothesize that the effectiveness of the myogenic programme is influenced by the levels of gastrointestinal hormones in the bloodstream, and this connection is associated with the onset of sarcopenia.

Methods

We first categorized 145 individuals from the Emergency Room of Taipei Veterans General Hospital into sarcopenia and non-sarcopenia groups, following the criteria established by the Asian Working Group for Sarcopenia. A thorough examination of specific gastrointestinal hormone levels in plasma was conducted to identi

SUBMITTER: Huang HH 

PROVIDER: S-EPMC11446708 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature