Change in physical activity and its association with decline in kidney function: A UK Biobank-based cohort study.

ABSTRACT:

Background

Previous research on the association between physical activity (PA) and kidney function is inconsistent. The association between muscle mass and serum creatinine (SCr) may have implications for interpreting the effect of PA on estimated glomerular filtration rate (eGFR). Few studies have reported changes in physical activity and changes in kidney function.

Methods

A cohort study was constructed using the UK Biobank. Changes in physical activity were self-reported as metabolic equivalent task (MET) minutes/week. eGFR was calculated using SCr and cystatin C (CysC). Cox and nonlinear regressions with restricted cubic splines were applied to explore the association between changes in physical activity and rapid decline of kidney function (RDKF, eGFR annual decrease ≥3

SUBMITTER: Liu Q 

PROVIDER: S-EPMC11446710 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature