DCAF2 is essential for the development of uterine epithelia and mouse fertility.

ABSTRACT:

Introduction

The successful outcome of a pregnancy depends on the proper functioning uterine epithelium. DNA damage binding protein 1 and cullin 4-associated factor 2 (DCAF2), a conserved substrate receptor for the cullin 4-RING E3 ubiquitin ligase (CRL4) complex, is essential for maintaining genome stability by facilitating ubiquitin-mediated degradation of substrates.

Methods

To better understand the physiological role of DCAF2 in female reproduction, we conducted a study using mice with conditional knockout (cKO) of DCAF2 in the uterus using the progesterone receptor Cre (Pgr ^Cre/+) mouse model.

Results

Our results showed the cKO mice were completely infertile, despite having ovarian function. The cKO mice exhibited severely thin uteri, demonstrat

SUBMITTER: Yang M 

PROVIDER: S-EPMC11446810 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature