Predicting visual function by interpreting a neuronal wiring diagram.

ABSTRACT: As connectomics advances, it will become commonplace to know far more about the structure of a nervous system than about its function. The starting point for many investigations will become neuronal wiring diagrams, which will be interpreted to make theoretical predictions about function. Here I demonstrate this emerging approach with the Drosophila optic lobe, analysing its structure to predict that three Dm3 (refs. ^1-4) and three TmY (refs. ^2,4) cell types are part of a circuit that serves the function of form vision. Receptive fields are predicted from connectivity, and suggest that the cell types encode the local orientation of a visual stimulus. Extraclassical^5,6 receptive fields are also predicted, with implications for robust orientation tuning⁷

SUBMITTER: Seung HS 

PROVIDER: S-EPMC11446822 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature