A Drosophila computational brain model reveals sensorimotor processing.

ABSTRACT: The recent assembly of the adult Drosophila melanogaster central brain connectome, containing more than 125,000 neurons and 50 million synaptic connections, provides a template for examining sensory processing throughout the brain^1,2. Here we create a leaky integrate-and-fire computational model of the entire Drosophila brain, on the basis of neural connectivity and neurotransmitter identity³, to study circuit properties of feeding and grooming behaviours. We show that activation of sugar-sensing or water-sensing gustatory neurons in the computational model accurately predicts neurons that respond to tastes and are required for feeding initiation⁴. In addition, using the model to activate neurons in the feeding region of the Drosophila brain predicts those

SUBMITTER: Shiu PK 

PROVIDER: S-EPMC11446845 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature