Comparative safety analysis of lacosamide and perampanel in epilepsy management: insights from FAERS database.

ABSTRACT:

Background

Epilepsy is a chronic neurological condition requiring effective management with minimal adverse effects. Lacosamide (LCM) and Perampanel (PER), two promising treatments, have distinct profiles that merit comparative analysis to guide clinical decision-making.

Methods

This study utilizes a pharmacovigilance analysis of adverse events reported in the FDA Adverse Event Reporting System database from Q1 2009 to Q3 2023. Employing disproportionality and Bayesian analyses, we assessed and compared the AE signals associated with LCM and PER to elucidate their safety profiles in epilepsy treatment.

Results

The analysis included 12,576 AE reports for LCM and 2,703 for PER, highlighting a higher incidence of psychiatric disorders, including aggression with LCM, and

SUBMITTER: Ge C 

PROVIDER: S-EPMC11446851 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature