Driver gene alterations in NSCLC patients in southern China and their correlation with clinicopathologic characteristics.

ABSTRACT:

Introduction

In this study, we aimed to explore the relationship between clinicopathological features and driver gene changes in Chinese NSCLC patients.

Methods

Amplification refractory mutation system PCR was used to detect the aberrations of 10 driver oncogenes in 851 Chinese NSCLC patients, and their correlation with clinicopathological characteristics was also analyzed. Moreover, three models of logistic regression were used to analyze the association between histopathology and EGFR or KRAS mutations.

Results

The top two most frequently aberrant target oncogenes were EGFR (48.06%) and KRAS (9.51%). These were followed by ALK (5.41%), HER2 (2.35%), MET (2.23%), RET (2.11%), ROS1 (1.88%), BRAF (0.

SUBMITTER: Deng L 

PROVIDER: S-EPMC11446855 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature