A virulence-associated small RNA MTS1338 activates an ABC transporter CydC for rifampicin efflux in <i>Mycobacterium tuberculosis</i>.

ABSTRACT: The efficacy of the tuberculosis treatment is restricted by innate drug resistance of Mycobacterial tuberculosis and its ability to acquire resistance to all anti-tuberculosis drugs in clinical use. A profound understanding of bacterial ploys that decrease the effectiveness of drugs would identify new mechanisms for drug resistance, which would subsequently lead to the development of more potent TB therapies. In the current study, we identified a virulence-associated small RNA (sRNA) MTS1338-driven drug efflux mechanism in M. tuberculosis. The treatment of a frontline antitubercular drug rifampicin upregulated MTS1338 by >4-fold. Higher intrabacterial abundance of MTS1338 increased the growth rate of cells in rifampicin-treated conditions. This fact was attributed by the upre

SUBMITTER: Singh S 

PROVIDER: S-EPMC11446857 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature