Optimizing tacrolimus dosing in Hispanic renal transplant patients: insights from real-world data.

ABSTRACT:

Aim

Tacrolimus, an immunosuppressant used to prevent organ rejection in renal transplant patients, exhibits high inter-patient variability, necessitating therapeutic drug monitoring. Early post-transplant tacrolimus exposure in Hispanics is understudied. Although genotypic information is linked to pharmacokinetic differences, its clinical application remains limited. This study aimed to use a real-world data-driven, pharmacokinetic model-based approach for tacrolimus in Hispanics to determine a suitable initial dose and design an optimal dose titration strategy by simulations to achieve plasma trough concentration target levels of 10-12 ng/mL at the earliest.

Methods

Sparse concentration-time data of tacrolimus were obtained from electronic medical records for self-identifie

SUBMITTER: Chamzas A 

PROVIDER: S-EPMC11446860 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature