Circulating extracellular vesicles as novel biomarkers for pulmonary arterial hypertension in patients with systemic lupus erythematosus.

ABSTRACT:

Introduction

Pulmonary arterial hypertension (PAH) is a serious complication of systemic lupus erythematosus (SLE) with increased mortality. A prothrombotic state may contribute to pathogenesis of SLE-PAH. Extracellular vesicles (EVs) are known to be associated with thrombosis. Here, we investigated circulating EVs and their associations with SLE-PAH.

Methods

Eighteen SLE-PAH patients, 36 SLE-non-PAH patients, and 36 healthy controls (HCs) were enrolled. Flow cytometry was used to analyze circulating EVs from leukocytes (LEVs), red blood cells (REVs), platelets (PEVs), endothelial cells (EEVs), and Annexin V⁺ EVs with membrane phosphatidylserine (PS) exposure.

Results

Plasma levels of all EV subgroups were elevated in SLE patients with or without PAH compar

SUBMITTER: Ding Z 

PROVIDER: S-EPMC11446868 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature