Associations between antagonistic SNPs for neuropsychiatric disorders and human brain structure.

ABSTRACT: A previously published genome-wide association study (GWAS) meta-analysis across eight neuropsychiatric disorders identified antagonistic single-nucleotide polymorphisms (SNPs) at eleven genomic loci where the same allele was protective against one neuropsychiatric disorder and increased the risk for another. Until now, these antagonistic SNPs have not been further investigated regarding their link to brain structural phenotypes. Here, we explored their associations with cortical surface area and cortical thickness (in 34 brain regions and one global measure each) as well as the volumes of eight subcortical structures using summary statistics of large-scale GWAS of brain structural phenotypes. We assessed if significantly associated brain structural phenotypes were previously reported to b

SUBMITTER: Federmann LM 

PROVIDER: S-EPMC11446931 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature