LEAP2, a ghrelin receptor inverse agonist, and its effect on alcohol-related responses in rodents.

ABSTRACT: The underlying neurobiology of alcohol use disorder (AUD) is complex and needs further unraveling, with one of the key mechanisms being the gut-brain peptide ghrelin and its receptor (GHSR). However, additional substrates of the ghrelin pathway, such as liver-expressed antimicrobial peptide 2 (LEAP2), an endogenous GHSR inverse agonist, may contribute to this neurobiological framework. While LEAP2 modulates feeding and reward through central mechanisms, its effects on alcohol responses are unknown. The aim of the present study was therefore to identify the impact of central LEAP2 on the ability of alcohol to activate the mesolimbic dopamine system and to define its ability to control alcohol intake. These experiments revealed that central LEAP2 (i.e. into the third ventricle) prevented the

SUBMITTER: Tufvesson-Alm M 

PROVIDER: S-EPMC11446955 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature