Gene expression of Decompression Sickness-resistant rats through a miRnome/transcriptome crossed approach.

ABSTRACT: Susceptibility to decompression sickness (DCS) is characterized by a wide inter-individual variability, the origins of which are still poorly understood. We selectively bred rats with at least a 3-fold greater resistance to DCS than standard rats after 6 generations. In order to better understand DCS mechanisms, we compared the static genome expression of these resistant rats from the 10^th generation to their counterparts of the initial non-resistant Wistar strain, by a microarray transcriptomic approach coupled and crossed with a PCR plates miRnome study. Thus, we identified differentially expressed genes on selected males and females, as well as gender differences in those genes, and we crossed these transcripts with the respective targets of the differentially expressed micro

SUBMITTER: Dugrenot E 

PROVIDER: S-EPMC11446962 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature