Immune checkpoint inhibitors-associated cranial nerves involvement: a systematic literature review on 136 patients.

ABSTRACT:

Objective

Describe the demographic data and clinical phenotype of cranial palsy induced by immune checkpoint inhibitors (CNP-ICI).

Methods

A systematic literature review of the literature was performed in Pubmed, Web of Science, and Embase, including 68 articles and 136 patients (PROSPERO no. CRD42024517262).

Results

Out of the 1205 articles screened, 68 articles were included after fulfilling the inclusion criteria, for a total of 136 patients. All articles were case reports and case series. In the cohort studied, 52% of patients were treated with anti PD-1/PDL-1 therapies, 14% with anti CTLA-4 therapies, and 34% with a combination of anti CTLA-4 and anti PD-1/PDL-1 therapies. The facial nerve was the most affected cranial nerve, involved in 38% of cases, followed by

SUBMITTER: Pichon S 

PROVIDER: S-EPMC11446990 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature