Single-cell RNA sequencing reveals transcriptomic landscape and potential targets for human testicular ageing.

ABSTRACT:

Study question

What is the molecular landscape underlying the functional decline of human testicular ageing?

Summary answer

The present study provides a comprehensive single-cell transcriptomic atlas of testes from young and old humans and offers insights into the molecular mechanisms and potential targets for human testicular ageing.

What is known already

Testicular ageing is known to cause male age-related fertility decline and hypogonadism. Dysfunction of testicular cells has been considered as a key factor for testicular ageing.

Study design, size, duration

Human testicular biopsies were collected from three young individuals and three old individuals to perform single-cell RNA sequencing (scRNA-seq). The key results were validated in a larger cohort contai

SUBMITTER: Xia K 

PROVIDER: S-EPMC11447013 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature