Neutral evolution of rare cancer mutations in the computer and the clinic.

ABSTRACT: A distinct model of neutral evolution of rare cancer mutations is described and contrasted with models relying on the infinite sites approximation (that a specific mutation arises in only one cell at any instant). An explosion of genetic diversity is predicted at clinical cell numbers and may explain the progressive refractoriness of cancers during a clinical course. The widely used infinite sites assumption may not be applicable for clinical cancers.

SUBMITTER: Beckman RA 

PROVIDER: S-EPMC11447017 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature