The frequency of CD38⁺ alveolar macrophages correlates with early control of M. tuberculosis in the murine lung.

ABSTRACT: Tuberculosis, caused by Mycobacterium tuberculosis, remains an enduring global health challenge due to the limited efficacy of existing treatments. Although much research has focused on immune failure, the role of host macrophage biology in controlling the disease remains underappreciated. Here we show, through multi-modal single-cell RNA sequencing in a murine model, that different alveolar macrophage subsets play distinct roles in either advancing or controlling the disease. Initially, alveolar macrophages that are negative for the CD38 marker are the main infected population. As the infection progresses, CD38⁺ monocyte-derived and tissue-resident alveolar macrophages emerge as significant controllers of bacterial growth. These macrophages display a unique chromatin organizati

SUBMITTER: Pisu D 

PROVIDER: S-EPMC11447019 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature