Prognostic and therapeutic implications of tumor-restrictive type III collagen in the breast cancer microenvironment.

ABSTRACT: Collagen plays a critical role in regulating breast cancer progression and therapeutic resistance. An improved understanding of both the features and drivers of tumor-permissive and -restrictive collagen matrices are critical to improve prognostication and develop more effective therapeutic strategies. In this study, using a combination of in vitro, in vivo and bioinformatic experiments, we show that type III collagen (Col3) plays a tumor-restrictive role in human breast cancer. We demonstrate that Col3-deficient, human fibroblasts produce tumor-permissive collagen matrices that drive cell proliferation and suppress apoptosis in non-invasive and invasive breast cancer cell lines. In human triple-negative breast cancer biopsy samples, we demonstrate elevated deposition of Col3 relative to t

SUBMITTER: Stewart DC 

PROVIDER: S-EPMC11447064 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature