Tumor-related epilepsy in high-grade glioma: a large series survival analysis.

ABSTRACT:

Purpose

Seizures are a common clinical occurrence in high-grade glioma (HGG). While many studies have explored seizure incidence and prevalence in HGG, limited studies have examined the prognostic effect of seizures occurring in the post-diagnosis setting. This study aims to assess the impact of seizure presentation on HGG survival outcomes.

Methods

Single-center retrospective review identified 950 patients with histologically-confirmed high-grade glioma. Seizure presentation was determined by clinical history and classified as early onset (occurring within 30 days of HGG presentation) or late onset (first seizure occurring after beginning HGG treatment). The primary outcome, hazard ratios for overall survival and progression-free survival, was assessed with multivariable Co

SUBMITTER: Rilinger RG 

PROVIDER: S-EPMC11447087 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature