NitraTh epitope-based neoantigen vaccines for effective tumor immunotherapy.

ABSTRACT: Neoantigen vaccines represent an emerging and promising strategy in the field of tumor immunotherapy. Despite their potential, designing an effective neoantigen vaccine remains a challenge due to the current limitations in predicting CD4⁺ T cell epitopes with high accuracy. Here, we introduce a novel approach to neoantigen vaccine design that does not rely on computational prediction of CD4⁺ T cell epitopes. Utilizing nitrated helper T cell epitope containing p-nitrophenylalanine, termed "NitraTh epitope," we have successfully engineered a series of tumor neoantigen vaccines capable of eliciting robust neoantigen-specific immune responses. With the help of NitraTh epitope, even mutations with low predicted affinity for MHC class I molecules were successfully induced t

SUBMITTER: Zhang W 

PROVIDER: S-EPMC11447171 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature