HLA-G neo-expression modifies genetic programs governing tumor cell lines.

ABSTRACT: The development of immunotherapies has proved to be clinically encouraging to re-establish the immune function modified by the expression of immune inhibitory molecules in tumors. However, there are still patients with poor survival rates following treatment. The elucidation of molecular mechanisms triggered by the neo-expression of particular IC in tumors would constitute a major step toward better understanding tumor evolution and would help to design future clinical protocols. To this end, we investigate the modifications triggered by the neo-expression of the immune checkpoints HLA-G in ccRCC tumor cells. We demonstrate, for the first time, that HLA-G modifies key genes implicated mainly in tumor development, angiogenesis, calcium flow and mitochondria dynamics. The involvement of HLA-

SUBMITTER: Tronik-Le Roux D 

PROVIDER: S-EPMC11447172 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature