Discordant definitions of small airway dysfunction between spirometry and parametric response mapping: the HRCT-based study.

ABSTRACT:

Objectives

To analyze the lung structure of small airway dysfunction (SAD) defined by spirometry and parametric response mapping (PRM) using high-resolution computed tomography (HRCT), and to analyze the predictive factors for SAD.

Methods

A prospective study was conducted with 388 participants undergoing pulmonary function test (PFT) and inspiratory-expiratory chest CT scans. The clinical data and HRCT assessments of SAD patients defined by both methods were compared. A prediction model for SAD was constructed based on logistic regression.

Results

SAD was defined in 122 individuals by spirometry and 158 by PRM. In HRCT visual assessment, emphysema, tree-in-bud sign, and bronchial wall thickening have higher incidence in SAD defined by each method. (p < 0.001). Quanti

SUBMITTER: Chen B 

PROVIDER: S-EPMC11447176 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature