Structural basis of thiamine transport and drug recognition by SLC19A3.

ABSTRACT: Thiamine (vitamin B₁) functions as an essential coenzyme in cells. Humans and other mammals cannot synthesise this vitamin de novo and thus have to take it up from their diet. Eventually, every cell needs to import thiamine across its plasma membrane, which is mainly mediated by the two specific thiamine transporters SLC19A2 and SLC19A3. Loss of function mutations in either of these transporters lead to detrimental, life-threatening metabolic disorders. SLC19A3 is furthermore a major site of drug interactions. Many medications, including antidepressants, antibiotics and chemotherapeutics are known to inhibit this transporter, with potentially fatal consequences for patients. Despite a thorough functional characterisation over the past two decades, the structural basis of its tra

SUBMITTER: Gabriel F 

PROVIDER: S-EPMC11447181 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature