The relationship between COMT, proline, and negative symptoms in clinical high risk and recent psychosis onset.

ABSTRACT: Individuals at clinical high-risk (CHR) of developing psychosis, as well as patients with recent psychosis onset (RO), experience significant negative symptoms that detrimentally impact daily-life functioning and are associated with poor outcomes, even in those who do not convert to psychosis. Targeting negative symptoms may thus hold promise for the treatment of CHR and RO patients. Building from previous findings we examined whether the catechol-O-methyltransferase (COMT) Val¹⁵⁸Met functional polymorphism and fasting peripheral proline concentration predicts the severity of negative symptoms experienced by adolescents and young adults at CHR or those with RO. As hypothesized, the interaction between fasting plasma proline and COMT predicted negative symptoms, as measured via t

SUBMITTER: Clelland JD 

PROVIDER: S-EPMC11447206 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature