Stanniocalcin 1 and 1,25-dihydroxyvitamin D₃ cooperatively regulate bone mineralization by osteoblasts.

ABSTRACT: Stanniocalcin 1 (STC1) is a calcium- and phosphate-regulating hormone that is expressed in all tissues, including bone tissues, and is involved in calcium and phosphate homeostasis. Previously, STC1 expression was found to be increased by 1,25-dihydroxyvitamin D₃ [1,25(OH)₂D₃] administration in renal proximal tubular cells. In this study, we investigated whether STC1 directly regulates osteoblast differentiation or reciprocally controls the effects of 1,25(OH)₂D₃ on osteoblasts to contribute to bone homeostasis. We found that STC1 inhibited osteoblast differentiation in vitro and bone morphogenetic protein 2 (BMP2)-induced ectopic bone formation in vivo. Moreover, 1,25(OH)₂D₃ increased STC1 expression through dire

SUBMITTER: Kim JH 

PROVIDER: S-EPMC11447260 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature