Sex differences in DNA methylation variations according to ART conception-evidence from the Norwegian mother, father, and child cohort study.

ABSTRACT: Previous studies have shown cord-blood DNA methylation differences in newborns conceived using assisted reproductive technologies (ART) compared to those conceived naturally. However, whether these ART-related DNA methylation differences vary with children's sex is unknown. We hypothesize that the DNA methylation differences in cord blood between ART-conceived and naturally conceived newborns also varies by the sex of the child, with distinct patterns of differential methylation present in males and females. We investigated sex differences in cord-blood DNA methylation variation according to conception by ART using the Illumina MethylationEPIC platform, comparing 456 ART-conceived versus 507 naturally-conceived girls, and 503 ART-conceived and 473 naturally-conceived boys. We identified 37

SUBMITTER: Kristjansson D 

PROVIDER: S-EPMC11447267 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature