A cause-effect relationship between uterine diseases and breast cancer: A bidirectional Mendelian randomization study.

ABSTRACT:

Objective

To explore the cause-effect relationship between uterine diseases (UDs) and breast cancer (BC) and underlying mechanism of the cause-effect relationship, enhance understanding of the association between BC and UDs.

Methods

A two-sample bidirectional Mendelian randomization (MR) analysis was conducted. We obtained summary statistics data from GWAS for BC, endometriosis, endometrial cancer (EC), uterine leiomyoma (UL), uterine polyps (UP), and cervical cancer (CC). Independent SNPs were selected as instrumental variables (IVs) for each disease. The inverse variance weighted (IVW) method was primary used for estimating the causal association between UDs and BC. To further evaluate the consistency and dependability of the results, we also utilized the weighted median,

SUBMITTER: Liu Z 

PROVIDER: S-EPMC11447327 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature