The TolC and Lipopolysaccharide-Specific <i>Escherichia coli</i> Bacteriophage TLS-the <i>Tlsvirus</i> Archetype Virus.

ABSTRACT:

Introduction

TLS is a virulent bacteriophage of Escherichia coli that utilizes TolC and lipopolysaccharide as its cell surface receptors.

Methods

The genome was reannotated using the latest online resources and compared to other T1-like phages.

Results

The TLS genome consists of 49,902 base pairs, encoding 86 coding sequences that display considerable sequence similarity with the T1 phage genome. It also contains 18 intergenic 21-base long repeats, each of them upstream of a predicted start codon and in the direction of transcription. Data revealed that DNA packaging occurs through the pac site-mediated headful mechanism.

Conclusions

Based on sequence analysis of its genome, TLS belongs to the Drexlerviridae family and represents the type m

SUBMITTER: German GJ 

PROVIDER: S-EPMC11447400 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature