A meta-analysis of cognitive flexibility in aging: Perspective from functional network and lateralization.

ABSTRACT: Cognitive flexibility, the ability to switch between mental processes to generate appropriate behavioral responses, is reduced with typical aging. Previous studies have found that age-related declines in cognitive flexibility are often accompanied by variations in the activation of multiple regions. However, no meta-analyses have examined the relationship between cognitive flexibility in aging and age-related variations in activation within large-scale networks. Here, we conducted a meta-analysis employing multilevel kernel density analysis to identify regions with different activity patterns between age groups, and determined how these regions fall into functional networks. We also employed lateralization analysis to explore the spatial distribution of regions exhibiting group differences

SUBMITTER: Xia H 

PROVIDER: S-EPMC11447525 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature