Lithium Aspartate for Long COVID Fatigue and Cognitive Dysfunction: A Randomized Clinical Trial.

ABSTRACT:

Importance

Neurologic post-COVID-19 condition (PCC), or long COVID, symptoms of fatigue and cognitive dysfunction continue to affect millions of people who have been infected with SARS-CoV-2. There currently are no effective evidence-based therapies available for treating neurologic PCC.

Objective

To assess the effects of lithium aspartate therapy on PCC fatigue and cognitive dysfunction.

Design, setting, and participants

A randomized, double-blind, placebo-controlled trial (RCT) enrolling participants in a neurology clinic from November 28, 2022, to June 29, 2023, with 3 weeks of follow-up, was conducted. Subsequently, an open-label lithium dose-finding study with 6 weeks of follow-up was performed among the same participants enrolled in the RCT. Eligible individuals

SUBMITTER: Guttuso T 

PROVIDER: S-EPMC11447566 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature