Eight-Week Supplementation With Bifidobacterium lactis HN019 and Functional Constipation: A Randomized Clinical Trial.

ABSTRACT:

Importance

Probiotic supplementation may improve bowel movements. However, large, properly designed studies are lacking.

Objective

To evaluate the potential benefit of Bifidobacterium animalis subsp lactis HN019 on constipation, expressed as complete spontaneous bowel movements (CSBMs).

Design, setting, and participants

This randomized triple-blind placebo-controlled clinical trial with 2 weeks of run-in and 8 weeks of intervention was conducted from December 25, 2020, to February 28, 2022, at 5 hospitals in Shanghai, China. Participants included healthy volunteers with functional constipation according to Rome III criteria, 18 to 70 years of age, and a body mass index (calculated as the weight in kilograms divided by the height in meters squared) of less than 30.0. E

SUBMITTER: Cheng J 

PROVIDER: S-EPMC11447574 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature