Tranexamic Acid During Radical Cystectomy: A Randomized Clinical Trial.

ABSTRACT:

Importance

Among cancer surgeries, patients requiring open radical cystectomy have the highest risk of red blood cell (RBC) transfusion. Prophylactic tranexamic acid (TXA) reduces blood loss during cardiac and orthopedic surgery, and it is possible that similar effects of TXA would be observed during radical cystectomy.

Objective

To determine whether TXA, administered before incision and for the duration of radical cystectomy, reduced the number of RBC transfusions received by patients up to 30 days after surgery.

Design, setting, and participants

The Tranexamic Acid During Cystectomy Trial (TACT) was a double-blind, placebo-controlled, randomized clinical trial with enrollment between June 2013 and January 2021. This multicenter trial was conducted in 10 academic cen

SUBMITTER: Breau RH 

PROVIDER: S-EPMC11447623 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature