Highly sensitive label-free biomolecular detection using Au-WS₂ nanohybrid based SERS substrates.

ABSTRACT: Recent advancements in nanotechnology have led to the development of surface-enhanced Raman spectroscopy (SERS) based rapid and low-cost technologies for ultra-sensitive label-free detection and identification of molecular analytes. Herein, we utilized the synergistic plasmonic and chemical enhancement effects of Au-WS₂ nanohybrids to attain the high-intensity Raman signals of targeted analytes. To develop these nanohybrids, a series of monodispersed Au nanoparticles (NPs) of varying diameters from 20 to 80 nm was chemically synthesized and successively blended with liquid-phase exfoliated WS₂ nano-flakes of average lateral size 90 nm. They provided a maximum enhancement factor (EF) of ∼1.80 × 10⁹ corresponding to the characteristic peaks at 1364 cm^-1<

SUBMITTER: Prakash O 

PROVIDER: S-EPMC11447697 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature