Microwave-Assisted Hydrolysis of Ethyl Azolylacetates and Cinnamates with K₂CO₃: Synthesis of Potassium Carboxylates.

ABSTRACT: In this study, the hydrolysis of ethyl azolylacetates and ethyl cinnamates using K₂CO₃/ethanol under microwave irradiation was developed. For this purpose, ethyl azolylacetates were first synthesized by nucleophilic substitution between the corresponding azole and ethyl bromoacetate under sonication at 50 °C for 3 h, yielding derivatives with 10-92% chemical yields, while ethyl cinnamates were obtained by a microwave-assisted Horner-Wadsworth-Emmons (HWE) reaction of triethyl phosphonoacetate with a variety of aryl aldehydes at 140 °C for 20 min, yielding derivatives with moderate to high yields (67-98%). Initially, the optimization of the hydrolysis reaction was performed using ethyl pyrazolylacetate as a model starting material while varying the temperature, time, a

SUBMITTER: Hernandez-Fernandez J 

PROVIDER: S-EPMC11447747 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature