Treatment of Spontaneous Tumors With Algorithmically Controlled Electroporation.

ABSTRACT:

Objective

To study the safety and efficacy of algorithmically controlled electroporation (ACE) against spontaneous equine melanoma.

Methods

A custom temperature sensing coaxial electrode was paired with a high voltage pulse generation system with integrated temperature feedback controls. Computational modeling and ex vivo studies were conducted to evaluate the system's ability to achieve and maintain target temperatures. Twenty-five equine melanoma tumors were treated with a 2000 V protocol consisting of a 2-5-2 waveform, 45 °C temperature set point, and integrated energized times of 0.005 s, 0.01 s, or 0.02 s (2500x, 5000x, and 10000x 2 μs pulses, respectively). Patients returned 20-50 days post treatment to determine the efficacy of the treatment.

Results

ACE temper

SUBMITTER: Fesmire CC 

PROVIDER: S-EPMC11447859 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature