Fusobacterium nucleatum, immune responses, and metastatic organ diversity in colorectal cancer liver metastasis.

ABSTRACT: The presence of Fusobacterium nucleatum is associated with an immunosuppressive tumor immune microenvironment (TIM) in primary colorectal cancer (CRC), contributing to tumor progression. Its persistence in CRC liver metastasis tissues raises questions about its role in modulating local and systemic immune responses and influencing recurrence patterns. This retrospective cohort study of 218 patients with CRC liver metastasis investigated the association of F. nucleatum in CRC liver metastasis tissues with systemic inflammation, TIM alterations, and the number of metastatic organs involved in recurrence. Two-step polymerase chain reaction (PCR), including digital PCR, detected F. nucleatum in 42% (92/218) of fresh-frozen specimens of CRC liver metastases. Compared with the F. nucleatum-none

SUBMITTER: Shigematsu Y 

PROVIDER: S-EPMC11447885 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature