Chaotropic Agent-Assisted Supported Lipid Bilayer Formation.

ABSTRACT: Supported lipid bilayers (SLBs) are useful structures for mimicking cellular membranes, and they can be integrated with a variety of sensors. Although there are a variety of methods for forming SLBs, many of these methods come with limitations in terms of the lipid compositions that can be employed and the substrates upon which the SLBs can be deposited. Here we demonstrate the use of an all-aqueous chaotropic agent exchange process that can be used to form SLBs on two different substrate materials: SiO₂, which is compatible with traditional SLB formation by vesicle fusion, and Al₂O₃, which is not compatible with vesicle fusion. When examined with a quartz crystal microbalance with dissipation monitoring, the SLBs generated by chaotropic agent exchange (CAS

SUBMITTER: Cawley JL 

PROVIDER: S-EPMC11447895 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature