Behavioral screening of sleep-promoting effects of human intestinal and food-associated bacteria on Drosophila melanogaster.

ABSTRACT: Commensal microbes influence various aspects of vertebrate and invertebrate brain function. We previously reported that Lactiplantibacillus plantarum SBT2227 promotes sleep in the fruit fly, Drosophila melanogaster. However, how widely the sleep-promoting effects are conserved in gut bacterial species remains unknown. In this study, we orally administered human intestinal and food-associated bacterial species (39 in total) to flies and investigated their effects on sleep. Six species of bacteria were found to have significant sleep-promoting effects. Of these, we further investigated Bifidobacterium adolescentis, which had the greatest sleep-promoting effect, and found that the strength of the sleep effect varied among strains of the same bacterial species. The B. adolescentis strains BA27

SUBMITTER: Ko T 

PROVIDER: S-EPMC11447928 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature