C-H Labeling with [¹⁸F]Fluoride: An Emerging Methodology in Radiochemistry.

ABSTRACT: Fluorine-18 is the most routinely employed radioisotope for positron emission tomography, a dynamic nuclear imaging modality. The radiolabeling of C-H bonds is an attractive method for installing fluorine-18 into organic molecules since it can preclude the cumbersome prefunctionalization of requisite precursors. Although electrophilic "F⁺" reagents (e.g., [¹⁸F]F₂) are effective for C-H radiolabeling, state-of-the-art methodologies predominantly leverage high molar activity nucleophilic [¹⁸F]fluoride sources (e.g., [¹⁸F]KF) with substantial (pre)clinical advantages. Reflecting this, multiple nucleophilic C-H radiolabeling techniques of high utility have been disclosed over the past decade. However, the adoption of (pre)clinical C-H radi

SUBMITTER: Wright JS 

PROVIDER: S-EPMC11447958 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature