Unveiling hierarchy and spatial distribution of O⁶-methylguanine-DNA methyltransferase promoter methylation in World Health Organization grade 2-3 gliomas.

ABSTRACT: This study investigated the role of O⁶-methylguanine-DNA methyltransferase promoter (MGMTp) methylation hierarchy and heterogeneity in grade 2-3 gliomas, focusing on variations in chemotherapy benefits and resection dependency. A cohort of 668 newly diagnosed grade 2-3 gliomas, with comprehensive clinical, radiological, and molecular data, formed the basis of this analysis. The extent of resection was categorized into gross total resection (GTR ≥100%), subtotal resection (STR >90%), and partial resection (PR ≤90%). MGMTp methylation levels were examined using quantitative pyrosequencing. Our findings highlighted the critical role of GTR in improving the prognosis for astrocytomas (IDH1/2-mutant and 1p/19q non-codeleted), contrasting with its lesser significance for oligodendrogl

SUBMITTER: Li M 

PROVIDER: S-EPMC11447971 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature