Genomic and functional divergence of <i>Staphylococcus aureus</i> strains from atopic dermatitis patients and healthy individuals: insights from global and local scales.

ABSTRACT: Atopic dermatitis (AD) is the most common chronic inflammatory skin disease worldwide and is characterized by a complex interplay with skin microbiota, with Staphylococcus aureus often abnormally more abundant in AD patients than in healthy individuals (HE). S. aureus harbors diverse strains with varied genetic compositions and functionalities, which exhibit differential connections with the severity of AD. However, the differences in S. aureus strains between AD and HE remain unclear, with most variations seen at a specific geographic level, implying spontaneous adaptations rather than systematic distinctions. This study presents genomic and functional differences between these S. aureus strains from AD and HE on both global and local levels. We observed reduce

SUBMITTER: Wang Z 

PROVIDER: S-EPMC11448032 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature