Randomized control trial of moderate dose vitamin D alters microbiota stability and metabolite networks in healthy adults.

ABSTRACT: Evidence indicates that both vitamin D and the gut microbiome are involved in the process of colon carcinogenesis. However, it is unclear what effects supplemental vitamin D₃ has on the gut microbiome and its metabolites in healthy adults. We conducted a double-blind, randomized, placebo-controlled trial to identify the acute and long-term microbiota structural and metabolite changes that occur in response to a moderate dose (4,000 IU) of vitamin D₃ for 12 weeks in healthy adults. Our results demonstrated a significant increase in serum 25-hydroxy-vitamin D (25(OH)D) in the treatment group compared to placebo (P < 0.0001). Vitamin D₃ significantly increased compositional similarity (P < 0.0001) in the treatment group, and enriched members of t

SUBMITTER: Wyatt M 

PROVIDER: S-EPMC11448053 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature