Lipidomic analyses reveal distinctive variations in homeoviscous adaptation among clinical strains of <i>Acinetobacter baumannii</i>, providing insights from an environmental adaptation perspective.

ABSTRACT: Acinetobacter baumannii is known for its antibiotic resistance and is increasingly found outside of healthcare settings. To survive colder temperatures, bacteria, including A. baumannii, adapt by modifying glycerophospholipids (GPL) to maintain membrane flexibility. This study examines the lipid composition of six clinical A. baumannii strains, including the virulent AB5075, at two temperatures. At 18°C, five strains consistently show an increase in palmitoleic acid (C16:1), while ABVal2 uniquely shows an increase in oleic acid (C18:1). LC-HRMS2 analysis identifies shifts in GPL and glycerolipid composition between 18°C and 37°C, highlighting variations in phosphatidylethanolamine (PE) and phosphatidylglycerol (PG) lipids. ABVal2 shows increased PE with C18:1 and C16:1

SUBMITTER: Dessenne C 

PROVIDER: S-EPMC11448061 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature